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bepridil hydrochloride  (Tocris)


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    Structured Review

    Tocris bepridil hydrochloride
    Bepridil Hydrochloride, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bepridil+hydrochloride/Bepridil+hydrochloride/10__1096_slash_fj__202504690r-54-130-151
    Average 93 stars, based on 11 article reviews
    bepridil hydrochloride - by Bioz Stars, 2026-09
    93/100 stars

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    Incubation:

    Article Title: Pulsed infrared radiation excites cultured neonatal spiral and vestibular ganglion neurons by modulating mitochondrial calcium cycling
    Article Snippet: .. The neurons were incubated for 30 min at room temperature in the presence of either ammoniated ruthenium oxychloride (ruthenium red), 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one (CGP-37157), 2-aminoethoxydiphenylborane (2-APB), tetrodotoxin, ryanodine, 4-aminopyridine, bepridil hydrochloride, and cyclopiazonic acid (all 50 μM, and from Tocris Bioscience, Ellisville, MO) in artificial perilymph (with the exception of cyclopiazonic acid, which was diluted in Ca 2+ -free DPBS). ..

    Positron Emission Tomography:

    Article Title: Mechanism of 5‐Hydroxytryptamine Receptor 4 Mediated Vasorelaxation in the Isolated Bovine Lateral Saphenous Vein
    Article Snippet: To better understand the mechanisms of 5hydroxytryptamine receptor 4 (HTR4)mediated vasorelaxation, lateral saphenous veins from cattle (n = 4 to 7) were collected and assessed for vasoactivity in response to increasing concentrations of a selective HTR4 agonist (BIMU 8) in the absence and presence of inhibitors selective for downstream proteins involved with cyclic nucleotidemediated signaling.. Vessels were precontracted with 1 × 10−4 M phenylephrine and exposed to increasing HTR4 agonist concentrations.. Vasoactive response data were normalized as a percentage of the maximum contractile response induced by the phenylephrine precontraction.

    Phospho-proteomics:

    Article Title: Mechanism of 5‐Hydroxytryptamine Receptor 4 Mediated Vasorelaxation in the Isolated Bovine Lateral Saphenous Vein
    Article Snippet: To better understand the mechanisms of 5hydroxytryptamine receptor 4 (HTR4)mediated vasorelaxation, lateral saphenous veins from cattle (n = 4 to 7) were collected and assessed for vasoactivity in response to increasing concentrations of a selective HTR4 agonist (BIMU 8) in the absence and presence of inhibitors selective for downstream proteins involved with cyclic nucleotidemediated signaling.. Vessels were precontracted with 1 × 10−4 M phenylephrine and exposed to increasing HTR4 agonist concentrations.. Vasoactive response data were normalized as a percentage of the maximum contractile response induced by the phenylephrine precontraction.

    Concentration Assay:

    Article Title: Contractility measurements for cardiotoxicity screening with ventricular myocardial slices of pigs
    Article Snippet: .. Drugs from the CiPA list were added at five different concentration steps into 3–4 mL from the following stocks: bepridil hydrochloride (Tocris Bioscience, UK) 10 mM dissolved in DMSO; ibutilide hemifumarate (Sigma-Aldrich, USA) 10 μM dissolved in H 2 O; disopyramide phosphate (Sigma-Aldrich, USA) 10 mM dissolved in H 2 O; cisapride monohydrate 100 μM dissolved in DMSO; risperidone (Sigma-Aldrich, USA) 1 mM dissolved in DMSO; and acetylsalicylic acid (Sigma-Aldrich, USA) 100 μM dissolved in H 2 O. ..



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